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11, 23 Conversely, a minority of sporadic medullary thyroid carcinomas, namely 2/10 (20%), did express a measurable amount of GLP1R by immunohistochemistry in our study

Indirect calorimetry demonstrates higher fatty-acid oxidation and resting energy expenditure after dosing, consistent with an ERR-driven shift toward oxidative metabolism

Therefore, the implementation of a combined pharmacological therapy acting via different pathways becomes necessary, and its combination with a compound of the sulfonylurea group was along decades the most frequently employed prescription in routine clinical practice

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